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2 edition of Microtubules and microtubule inhibitors, 1980 found in the catalog.

Microtubules and microtubule inhibitors, 1980

Microtubules and microtubule inhibitors, 1980

Proceedings of the 2nd International Symposium on Microtubules and Microtubule Inhibitors, Beerse, Belgium, ... (Janssen Research Foundation series ; v. 3)

  • 31 Want to read
  • 8 Currently reading

Published by sole distributors for the USA and Canada, Elsevier North Holland .
Written in English


The Physical Object
Number of Pages576
ID Numbers
Open LibraryOL7531645M
ISBN 10044480305X
ISBN 109780444803054

  Microtubules and their polymerization dynamics. The polymerization of microtubules occurs by a nucleation-elongation mechanism in which the Cited by: MORRIS,N. R. The genetics of microtubule polymerization and the mechanism of action of antimicrotubule drugs in AspergiNus nidulans. In M. De Brabander and J. De Mey [eds.], Microtubules and microtubule inhibitors ,5 1 1. Elsevier/North-Holland Biomedical Press, Amsterdam.

Colchicine Inhibition of Microtubule Assembly via Copolymer Formation* (Received for publication, February 5, , and in revised form, ) Himan Sternlichtt and Israel Ringel From the Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio   Cellular Regulation of Microtubule Dynamics. Intracellular dynamic behavior of microtubules is regulated by a balance between activities of microtubule-stabilizing and microtubule-destabilizing proteins that include, in various cell types, a family of MAPs, tau, oncoprotein stathmin/oncoprot tumor suppressors BRCA1 and pVHL (von Hippel-Lindau syndrome) protein Cited by:

Learn mitotic inhibitors with free interactive flashcards. Choose from 37 different sets of mitotic inhibitors flashcards on Quizlet. Barrier disruption inhibits microtubule growth and hence destabilizes microtubules by targeting the regulatory proteins providing the microtubule polymerization and stability. An example represents thrombin which leads to Rho-dependent phosphorylation of tau and dephosphorylation of stathmin, promoting the disassembly of peripheral microtubule.


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Microtubules and microtubule inhibitors, 1980 Download PDF EPUB FB2

Get this from a library. Microtubules and microtubule inhibitors, proceedings of the 2nd International Symposium on Microtubules and Microtubule Inhibitors, Beerse, Belgium, August [M de Brabander; J de Mey; Janssen Research Foundation.; Belgian Society for Cell Biology.;]. Microtubule inhibitors.

The microtubule inhibitors are a class of compounds that inhibit the function of cellular microtubules. The microtubules are key structural elements of the cell cytoskeleton composed of polymers of tubulin.

Microtubules are engaged in cellular processes such as transport, cell shape, migration, and mitosis. Microtubules are polymers of tubulin that form part of the cytoskeleton and provide structure and shape to eukaryotic ubules can grow as long as 50 micrometres and are highly dynamic.

The outer diameter of a microtubule is between 23 and 27 nm while the inner diameter is between 11 and 15 nm. They are formed by the polymerization of a dimer of two globular proteins, alpha and beta.

Shortening of microtubules by αβ-tubulin dimer removal. Paclitaxel. Binds and stabilizes tubulin dimers, prevents depolymerization and affects microtubule dynamics. Docetaxel. Acetylation. Posttranslational modification affecting cargo trafficking.

Trichostatin A (TSA) Deacetylase inhibitor that increases microtubule acetylation. Tubulin inhibitors are chemotherapy drugs that interfere directly with the tubulin system, which is in contrast to those chemotherapy drugs acting on DNA.

Microtubules play an important role in eukaryotic - and beta-tubulin, the main components of microtubules, have gained considerable interest because of their function and biophysical properties and has become the subject of. Pages in category "Microtubule inhibitors" The following 19 pages are in this category, Microtubules and microtubule inhibitors of 19 total.

This list may not reflect recent changes (). 19 rows  M Nocodazole ≥99% (TLC), powder: Nocodazole is an antimitotic agent that disrupts. Microtubules, the third principal component of the cytoskeleton, are rigid hollow rods approximately 25 nm in diameter.

Like actin filaments, microtubules are dynamic structures that undergo continual assembly and disassembly within the cell.

They function both to determine cell shape and in a variety of cell movements, including some forms of cell locomotion, the intracellular transport of. microtubule-stabilizing and -destabilizing agents (Hartley et al., ). Microtubule-stabilizing agents, represented by taxol-like compounds, bind to the lateral side of tubulin, stabilizing the M-loop of b-tubulin, which establishes the lateral contacts of tubulin in microtubules (Prota et al., a).Cited by: A mitotic inhibitor is a drug that inhibits mitosis, or cell drugs disrupt microtubules, which are structures that pull the chromosomes apart when a cell c inhibitors are used in cancer treatment, because cancer cells are able to grow and eventually spread through the body (metastasize) through continuous mitotic division.

Function. MAPs bind to the tubulin subunits that make up microtubules to regulate their stability. A large variety of MAPs have been identified in many different cell types, and they have been found to carry out a wide range of include both stabilizing and destabilizing microtubules, guiding microtubules towards specific cellular locations, cross-linking microtubules and.

Microtubules are critically involved in regulating ER morphology, trafficking, and expansion of the organelle to the periphery of the cell by direct attachment of the ER to microtubules. Microtubule dynamics are tightly co-regulated with ER dynamics, which are suppressed by microtubule depolymerizing agents (, ).Cited by: Microtubules are found in biological cells as a part of the are hollow tubes whose walls consist of 13 columns of tubulin molecules.

Its main functions are to maintain a cell's shape, cell motility, chromosome movement in cell division, and organelle movement. They look like hollow noodles which transmit signals to our nerves.

References. Microtubule Inhibitors are generally applied preemergence to control annual grasses and some broadleaf weeds in many crops and turf grass.

These herbicides are absorbed by both roots and shoots of emerging seedlings but are not readily translocated. The emerging shoot is the primary absorption and action site in grass species.

Wilson L, Anderson K, Grisham L, Chin D: Biochemical mechanisms of action of microtubule inhibitors. In: Microtubules and microtubule inhibitors, Borgers M, de Brabander M (eds), North-Holland publishers,p – Google ScholarCited by: 1.

Microtubule Inhibitors. Microtubule inhibitors are used to treat ovarian cancer, breast cancer, lung cancer, kaposi's sarcoma, and prostate cancer. They work by stopping cancer cell growth and preventing the spread of the cells.

Microtubules are one of the most studied cellular components. There are MANY theories and speculations as to what they do. This page should be about what has been established. Microtubule modifications have been studied for close to 40 years, and is a well established field that has given us insights into how cell polarity is generated.

Xi J, Zhu X, Feng Y et al () Development of a novel class of tubulin inhibitors with promising anticancer activities. Mol Cancer Res 11(8)– doi: /MCR CrossRef PubMed Google ScholarCited by: Effects of microtubule and microfilament inhibitors on localization in the mitotic apparatus.

Microtubules of the spindle are disorganized but. Recently, microtubule stabilizing epothilones have been proposed for treatment of neurodegenerative disease and spinal cord damage.

Figure 1 illustrates how representative anti-microtubule drugs affect microtubule polymerization. Figure 1. Drugs that stabilize and destabilize microtubules provide useful medicines. Two classic examples are. Cytoskeletal drugs are small molecules that interact with actin or drugs can act on the cytoskeletal components within a cell in three main ways.

Some cytoskeletal drugs stabilize a component of the cytoskeleton, such as taxol which stabilizes microtubules or Phalloidin which stabilizes actin filaments.

Others such as Cytochalasin D bind to actin monomers and prevent them from.The effects of the microtubule inhibitors colchicine, parbendazole and nocodazole on the growth of myxamoebae of Physarum polycephalum were closely paralleled by the effects of these drugs on the.CYT is a potent microtubule polymerization inhibitor with IC50 of nM in cancer cell lines.

M Colchicine: Colchicine is a microtubule polymerization inhibitor with an IC50 of 3 nM. M Fosbretabulin disodium: Fosbretabulin disodium (Combretastatin A-4 phosphate) is a microtubule-targeting agent that binds β-tubulin with Kd of.